Results
| PMID | 24050030 |
| Gene Name | SAA1 |
| Condition | Endometriosis (Pelvic) |
| Association |
Associated |
| Population size | 76 |
| Population details | 76 (57 with endometriosis, 13 without endometriosis) |
| Sex | Female |
| Other associated phenotypes |
Pelvic endometriosis |
|
J Reprod Med. 2013 Sep-Oct;58(9-10):411-6. Ejzenberg, Dani| Podgaec, Sergio| Dias, Joao Antonio Jr| de Oliveira, Ricardo Manoel| Baracat, Edmund Chada| Abrao, Mauricio Simoes Endometriosis Unit, Division of Gynecology, Department of Obstetrics and Gynecology, School of Medicine, University of Sao Paulo, Brazil. OBJECTIVE: To evaluate serum and peritoneal concentrations of amyloid protein A in women with endometriosis and to compare them with those of women without endometriosis. STUDY DESIGN: A prospective study evaluated 76 women suspected of having pelvic endometriosis. Fifty-seven women (group A) were confirmed by videolaparoscopy and had their serum and peritoneal amyloid A concentrations measured by ELISA. The average levels from group A were compared to those obtained in group B. Group B was composed of 13 women without endometriosis, submitted to elective laparoscopy for tubal ligation. RESULTS: Peritoneal amyloid A concentrations in group A (310.3 +/- 97.8 ng/mL) were higher than those of group B (53.4 +/- 58.2 ng/mL); p = 0.0. However, serum concentrations in groups A (14.01 +/- 32.3 ng/mL) and B (9.5 +/- 15.9 ng/mL) did not differ significantly; p = 0.35. CONCLUSION: The peritoneal amyloid A protein concentration in pelvic endometriosis was higher when compared to normal controls, corroborating the inflammatory nature of the disease. This finding suggests that the procedure of evaluating the peritoneal amyloid A concentration in endometriosis merits further investigation. Mesh Terms: Adolescent| Adult| Ascitic Fluid/*chemistry| Endometriosis/blood/*diagnosis/metabolism| Female| Humans| Laparoscopy| Pelvic Inflammatory Disease/blood/*diagnosis/metabolism| Prospective Studies| Serum Amyloid A Protein/*analysis|DA 2013/10/31 06: |
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