Results
| PMID | 24127964 |
| Gene Name | BCL2 |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 30 |
| Population details | 30 women in reproductive age with a clinical or sonographic suspicion of endometrioma |
| Age | 25 – 39 yrs |
| Sex | Female |
| Associated genes | Bcl-2, Bax and Mcl-1 |
| Other associated phenotypes |
Severe endometriosis |
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J Obstet Gynaecol. 2013 Oct;33(7):725-8. doi: 10.3109/01443615.2013.824416. Korkmaz, D| Bastu, E| Dural, O| Yasa, C| Yavuz, E| Buyru, F Department of Obstetrics and Gynaecology, Medicana Bahcelievler Hospital. The aim of the study was to evaluate apoptosis through regulation of Bcl-2, Bax and Mcl-1 proteins by comparing their expressions in endometriotic cyst lesions and the endometrium of the patients with moderate to severe endometriosis. This is a cross-sectional study of 30 women in reproductive age with a clinical or sonographic suspicion of endometrioma, who underwent laparoscopy. Bcl-2 expression was positive both in cystic endometriotic lesions and endometrium, and its expression was significantly reduced in the cystic endometriotic lesions (p < 0.0001). There was a significant difference in Bcl-2 expression between cystic endometriotic stromal cells and endometrial stromal cells (p < 0.0001). Bax expression was positive both in cystic endometriotic lesions and endometrium, and its expression was significantly lower in the endometrium (p < 0.0001). There was a significant difference in Bax expression between cystic endometriotic stromal cells and endometrial stromal cells (p = 0.03). Mcl-1 expression was positive both in cystic endometriotic lesions and endometrium, and its expression was significantly lower in the cystic endometriotic lesions (p = 0.003). Apoptosis may play a role in the pathophysiology of endometriosis by potentially contributing to the survival of regurgitating endometrial cells in the peritoneal cavity. Mesh Terms: Adult| *Apoptosis| Cross-Sectional Studies| Cysts/metabolism| Endometriosis/*metabolism| Female| Humans| Myeloid Cell Leukemia Sequence 1 Protein/*metabolism| bcl-2-Associated X Protein/*metabolism|DA 2014/05/21 06:00 |
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