Results
| PMID | 24464013 |
| Gene Name | VIM |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 9 |
| Population details | 9 (8 women with stage III/IV endometriosis, 1 women with no signs of the disease) |
| Sex | Female |
| Associated genes | collagen ?1(XIV), calmodulin, collagen ?(VI), plexin, integrin ?V?3, transgelin, desmin, vimentin |
| Other associated phenotypes |
Ovarian endometrioid cysts, endometriosis |
|
Neuro Endocrinol Lett. 2013;34(7):717-21. Marianowski, Piotr| Szymusik, Iwona| Malejczyk, Jacek| Hibner, Michael| Wielgos, Miroslaw 1st Department of Obstetrics and Gynecology, Medical University of Warsaw, Poland. pmarianowski@poczta.onet.pl.| 1st Department of Obstetrics and Gynecology, Medical University of Warsaw, Poland.| Department of Histology and Embryology, Center for bio OBJECTIVE: The present study aimed at performing proteomic analysis of matched eutopic endometrium and ovarian endometrioid cysts from women with endometriosis in order to discover any abnormal protein expression related to the disease. DESIGN AND SETTING: The study included 8 women with stage III/IV endometriosis according to revised American Fertility Society (rAFS) classification and one woman with no signs of the disease as a reference. Proteomic analysis was performed using a novel isobaric tag-based methodology for relative and absolute peptide quanti fi cation (iTRAQ) coupled with multidimensional liquid chromatography and tandem mass spectrometry. RESULTS: The selection of 419 proteins was found in all endometriosis specimens. Using normal eutopic endometrium from woman without endometriosis as a reference, some proteins expressions were significantly increased in all endometriosis samples. They included collagen alpha1(XIV), calmodulin, collagen alpha(VI), plexin, integrin alphaVbeta3, transgelin, desmin, and vimentin. The comparison of these proteins' expression in paired eutopic and ovarian endometriosis samples has revealed that only vimentin was significantly increased in ovarian endometrioma. CONCLUSIONS: It was confirmed that endometriosis is associated with different expression of proteins in endometriotic samples. Nevertheless, further studies seem to be necessary as they may reveal possible markers that would be useful in clinical diagnosis of the disease. Mesh Terms: Adult| Choristoma/*metabolism| Chromatography, Liquid| Endometriosis/*diagnosis/*metabolism| Endometrium/*metabolism| Female| Humans| Ovary/*metabolism| Proteomics/*methods| Tandem Mass Spectrometry| Two-Dimensional Difference Gel Electrophoresi |
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