Results
| PMID | 24648304 |
| Gene Name | AZGP1 |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 10 |
| Population details | 10 (5 women with endometriosis, 5 without endometriosis); Another cohort (120 endometriosis, 20 healthy controls) |
| Sex | Female |
| Other associated phenotypes |
Endometriosis |
|
J Cell Physiol. 2014 Nov;229(11):1731-5. doi: 10.1002/jcp.24620. Signorile, Pietro Giulio| Baldi, Alfonso Centro Italiano Endometriosi, Rome, Italy. Endometriosis is estimated to affect 10% of women during the reproductive years. The lack of a non-invasive diagnostic test significantly contributes to the long delay between onset of the symptoms and definitive diagnosis of endometriosis. This case-control study was conducted to identify specific endometriosis antigens using 2D gel analysis in women with endometriosis (n = 5) and without endometriosis (n = 5). Differentially expresses spots were analyzed using matrix-assisted laser desorption/ionization-time-of-flight/mass spectrometry (nanoLC-ESI-MS/MS) with MASCOT analysis, in order to identify the corresponding proteins. ELISAs were performed on a different cohort of endometriosis (n = 120) and healthy patients (n = 20) in order to confirm the differential expression of the identified proteins. ROC analysis of ELISA results confirmed the statistical significance of the differential expression for one of these proteins: Zn-alpha2-glycoprotein (P = 0.019). We propose the analysis of the expression level of this protein in the serum as a new non-invasive diagnostic test for endometriosis. Mesh Terms: Adult| Biomarkers/*blood/chemistry| Case-Control Studies| Electrophoresis, Gel, Two-Dimensional| Endometriosis/*blood/*diagnosis| Female| Humans| Mass Spectrometry| Proteins/chemistry/metabolism| ROC Curve| Reproducibility of Results| Silver St |
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