Results
| PMID | 24845415 |
| Gene Name | VEGFA |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 81 |
| Population details | 81 (50 patients with endometriosis, 31 had no endometriosis ) |
| Age | 23-41 years |
| Sex | Female |
| Infertility type | Female infertility |
| Associated genes | IL-6 |
| Other associated phenotypes |
Endometriosis |
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Gynecol Endocrinol. 2014 Sep;30(9):671-5. doi: 10.3109/09513590.2014.920318. Epub Rathore, Neha| Kriplani, Alka| Yadav, Raj Kumar| Jaiswal, Urja| Netam, Ritesh Department of Physiology and. OBJECTIVE: The objective of the present study was to evaluate the levels of leptin, ghrelin, interleukin-6 (IL-6) and vascular endothelial growth factor (VEGF) in peritoneal fluid in patients with endometriosis and infertility, and study their correlation. DESIGN AND SETTING: This cross-sectional study included women undergoing diagnostic and/or therapeutic laparoscopy for endometriosis with chief complaint of infertility and/or pain at a tertiary care hospital. Based upon laparoscopic and histopathological findings, patients were categorized as with endometriosis and no endometriosis. Of the 50 patients with infertility (age 23-41 years), 19 had endometriosis while 31 had no endometriosis. The markers were assessed using ELISA kits. RESULTS: The median levels of leptin in patients with endometriosis (10.20 ng/mL) were higher (p = 0.04) and median levels of ghrelin in patients with endometriosis (150.4 pg/mL) were lower (p = 0.037) versus patients with no endometriosis (5.07 ng/mL and 229.6 pg/mL, respectively). The median levels of IL-6 and VEGF in patients with endometriosis were not different between the groups. The correlation analyses showed that leptin levels and IL-6 were positively correlated (p = 0.0001). CONCLUSIONS: The results suggest that ghrelin and leptin might play a key role in pathophysiology of endometriosis, and leptin is associated with inflammation in endometriosis. Mesh Terms: Adult| Ascitic Fluid/metabolism| Cross-Sectional Studies| Endometriosis/*complications/metabolism| Female| Ghrelin/*metabolism| Humans| Infertility, Female/*complications/metabolism| Interleukin-6/*metabolism| Leptin/*metabolism| Vascular Endoth |
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