Results
| PMID | 25666480 |
| Gene Name | COPS5 |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 54 |
| Population details | 54 (26 endometriosis, 28 non-endometriosis patients) |
| Sex | Female |
| Associated genes | Jab1, p27 |
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Arch Gynecol Obstet. 2015 Aug;292(2):377-81. doi: 10.1007/s00404-015-3642-0. Epub Kim, Tae-Hee| Lee, Hae-Hyeog| Chung, Soo-Ho| Park, Junsik| Lee, Arum Department of Obstetrics and Gynecology, Soonchunhyang University College of Medicine, Bucheon, 420-767, Republic of Korea. OBJECTIVE: The goal of this study was to investigate differential expression of the cell cycle signaling proteins p27 and Jun activation domain-binding protein 1 (Jab1) in benign ovarian cysts of patients with endometriosis compared to controls. METHODS: Ovarian tissues of 26 endometriosis and 28 non-endometriosis patients were used to evaluate expression of p27 and Jab1 by immunohistochemistry. RESULTS: There are no differences in clinical characteristics between the endometriosis and non-endometriosis group. In the endometriosis group, CD10, Jab1 and p27 were positive in 50, 48.3 and 57.7 % of cases, respectively, compared to 14.3, 17.9 and 50 %, respectively, in the non-endometriosis group. Jab1 and p27 were positive in 69.2 and 84.6 %, respectively, of the definite endometriosis cases. CONCLUSIONS: These results demonstrate that Jab1 expression was increased in endometriosis, while p27 expression was similar in the endometriosis and non-endometriosis groups. Mesh Terms: Adult| Case-Control Studies| Cell Cycle Proteins/metabolism| Cyclin-Dependent Kinase Inhibitor p27/*metabolism| Endometriosis/*metabolism| Female| Humans| Immunohistochemistry| Intracellular Signaling Peptides and Proteins/*metabolism| Middle Age |
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