Results
| PMID | 26054111 |
| Gene Name | PTGS2 |
| Condition | Endometriosis |
| Association |
Associated |
| Mutation | G to A at -1195 locus in the promoter region of COX-2 |
| Population size | 560 |
| Population details | 560 (170 cases of endometriosis, 150 cases of adenomyosis, 240 matched non-endometriosis and non-adenomyosis controls) |
| Sex | Female |
| Other associated phenotypes |
Endometriosis |
|
Clin Exp Obstet Gynecol. 2015;42(2):168-72. Wang, Y| Qu, Y| Song, W AIM: Ths study aims to explore the relationship between COX-2 gene polymorphism and the hereditary susceptibility or endoomeyriosis and adenomyosis. MATERIALS AND METHODS: Gene polymorphism in COX-2 gene was genotyped in 170 cases of endometriosis, 150 cases of adenomyosis, and 240 matched non-endometriosis and non-adenomyosis controls. RESULTS: Genotypic frequencies of GG, AG, and AA in COX-2 locus in endometriosis and adenomyosis were 16.5%, 51.2%, 32.4% and 16.0%, 49.3%, 34.7%, respectively. They were both significantly different from those in the control group (24.6%, 53.3%, and 22.1%) (p < 0.05). An allele frequency in endometriosis and adenomyosis were significantly higher than that in the control group. The risk of endometriosis or adenomyosis for those carrying two A alleles were 2.19 and 2.41 times to non-A genotype. CONCLUSION: Genetic variation of G to A at -1195 locus in the promoter region of COX-2 gene increases the risk of endometriosis and adenomyosis, and the genetic susceptibility of these two diseases are similar. Mesh Terms: Adenomyosis/*genetics| Adult| Case-Control Studies| China| Cyclooxygenase 2/*genetics| Endometriosis/*genetics| Female| Gene Frequency| Genetic Predisposition to Disease| Genotype| Humans| Polymorphism, Genetic| Polymorphism, Restriction Fragm |
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