Results
| PMID | 26059828 |
| Gene Name | RARRES2 |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 79 |
| Population details | 79 (31 women with endometriosis, 48 women without endometriosis) |
| Sex | Female |
| Associated genes | TNFA, IL-6 |
| Other associated phenotypes |
Endometriosis |
|
Am J Reprod Immunol. 2015 Oct;74(4):379-86. doi: 10.1111/aji.12405. Epub 2015 Jun Jin, Chan Hee| Yi, Kyong Wook| Ha, Young Ran| Shin, Jung-Ho| Park, Hyun Tae| Kim, Tak| Hur, Jun-Young Department of Obstetrics and Gynecology, College of Medicine, Eulji University, Daejeon, Korea.| Department of Obstetrics and Gynecology, College of Medicine, Korea University, Seoul, Korea.| Department of Obstetrics and Gynecology, College of Medicin PROBLEM: Inflammation is an essential process in the pathogenesis of endometriosis. METHOD OF STUDY: Serum and peritoneal fluid (PF) samples were collected from women with endometriosis (n = 31) and women without endometriosis (n = 48). Chemerin, tumor necrosis factor-alpha (TNF-alpha), and interleukin-6 (IL-6) levels in serum and PF samples were determined with a specific enzyme-linked immunosorbent assay. Eutopic endometrial tissue from controls and ovarian endometriotic cysts were obtained during surgery. Expression of chemerin and chemerin receptors in ectopic and eutopic endometrial tissues was measured on real-time reverse transcriptase-polymerase chain reaction. Protein expression was examined with Western blot and densitometric analysis. RESULTS: Chemerin concentrations were higher in PF from women with endometriosis than that in that from controls. PF chemerin concentrations were significantly correlated with both TNF-alpha and IL-6 levels in PF. The mRNA and protein of chemerin and its receptor were significantly increased in the ovarian endometrioma tissue compared with eutopic endometrium of controls. CONCLUSION: These findings suggest that chemerin plays a role in endometriosis-related pelvic inflammation. Mesh Terms: Adult| Ascitic Fluid/*metabolism| Chemokines/biosynthesis/*blood| Endometriosis/immunology/*pathology| Endometrium/immunology/*pathology/surgery| Enzyme-Linked Immunosorbent Assay| Female| Humans| Inflammation/immunology| Intercellular Signaling |
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