Results
| PMID | 26093350 |
| Gene Name | YBX1 |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 22 |
| Population details | 22 (12 patients with histologically confirmed endometriosis, 10 controls) |
| Sex | Female |
| Other associated phenotypes |
Endometriosis |
|
Eur J Obstet Gynecol Reprod Biol. 2015 Aug;191:68-71. doi: Ahrens, Thorben| Silveira, Cassia G T| Banz-Jansen, Constanze| Rody, Achim| Hornung, Daniela University of Lubeck, Department of Obstetrics and Gynecology, Lubeck, Germany. Electronic address: Thorben.Ahrens@uksh.de.| University of Lubeck, Department of Obstetrics and Gynecology, Lubeck, Germany; Laboratory of Clinical Immunology and Allergy-L OBJECTIVE: The objective of this study is the evaluation of serum YB-1 levels in the diagnosis of endometriosis. STUDY DESIGN: Serum samples of 12 patients with histologically confirmed endometriosis and of 10 control patients were collected. Western blot analysis was used to assess serum YB-1 levels. Groups were compared with Student's t-test or, if not normally distributed, with the Mann-Whitney test. Sensitivity and specificity for the potential diagnostic performance of serum YB-1 were assessed by receiver operating characteristic (ROC) curves. RESULTS: Serum YB-1 levels were significantly higher in patients with endometriosis (=0.004). The area under the curve was 0.867 (95% confidence interval 0.714-1.019) with sensitivity and specificity of 83.3% and 70% respectively. CONCLUSIONS: Serum YB-1 levels in patients with endometriosis are significantly higher compared to control patients and may be used as a potential diagnostic biomarker for endometriosis. Mesh Terms: Adult| Biomarkers/blood| Blotting, Western| Endometriosis/*blood/diagnosis/surgery| Female| Humans| Ovarian Diseases/*blood/diagnosis/surgery| ROC Curve| Sensitivity and Specificity| *Up-Regulation| Y-Box-Binding Protein 1/*blood|DA 2016/04/15 0 |
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