Results
| PMID | 26216523 |
| Gene Name | PTPN22 |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 380 |
| Population details | 380 (130 women hospitalized for endometriosis, 250 women without endometriosis) |
| Sex | Female |
| Associated genes | ACP1, ADA, PTPN22 |
| Other associated phenotypes |
Endometriosis |
|
Arch Gynecol Obstet. 2016 Feb;293(2):399-402. doi: 10.1007/s00404-015-3827-6. Gloria-Bottini, Fulvia| Ammendola, Maria| Saccucci, Patrizia| Neri, Anna| Magrini, Andrea| Bottini, Egidio Department of Biomedicine and Prevention, University of Rome Tor Vergata, Via Montpellier, 1, 00133, Rome, Italy. gloria@med.uniroma2.it.| Department of Obstetrics and Gynecology, P. Colombo Hospital, Velletri, 00049, Italy.| Department of Biomedicine PURPOSE: Association between p53 codon 72 and endometriosis has been observed in populations of East Asia but not in those of European descent. Genetic polymorphisms could interact with p53 codon 72 influencing its association with endometriosis, thus explaining these differences among populations. METHODS: 130 women hospitalized for endometriosis and a sample of 250 women without endometriosis have been studied. All women were from the White population of Rome. ACP1, PTPN22, ADA6 and p53 codon 72 genotypes were determined by DNA analysis. Statistical analysis was performed by SPSS package. Three-way contingency table analyses were performed by a log linear model according to Sokal and Rohlf. RESULTS: There is an epistatic interaction among ADA6, p53 codon 72 and endometriosis resulting in a positive association between carriers of *Pro allele of p53 codon 72 and endometriosis in women carrying the ADA6 *1 allele. PTPN22 and ACP1 show an additive effect with p53 codon 72 concerning their effect on endometriosis. The strength of association between p53 codon 72 and endometriosis is positively correlated with the number of the three factors considered. CONCLUSION: ADA6, PTPN22 and ACP1 are involved in immune reactions: since endometriosis has an autoimmune component, a cooperative interaction among these genetic systems appears biological plausible. The present result could contribute to explain the differences observed among populations concerning the association between p53 codon 72 and endometriosis. Mesh Terms: Adenosine Deaminase/*genetics| Adult| Alleles| Case-Control Studies| Codon/*genetics| Endometriosis/*genetics| European Continental Ancestry Group/*genetics| Female| Genetic Predisposition to Disease| Genotype| Humans| Middle Aged| Polymorphis |
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