Endometriosis Knowledgebase


A repository for genes associated with endometriosis

Results


PMID 26530052
Gene Name NR5A2
Condition Endometriosis
Association Associated
Population size 44
Population details 44 (16 patients with endometriosis and 28 controls)
Sex Female
Infertility type Female infertility
Associated genes CYP19, PII, LRH-1 and SF-1
Other associated phenotypes Endometriosis
Liver receptor homologue-1 and steroidogenic factor-1 expression in cultured granulosa cells from patients with endometriosis: A preliminary study.

J Obstet Gynaecol Res. 2015 Dec;41(12):1927-34. doi: 10.1111/jog.12832. Epub 2015

Lu, Xiang| Wu, Zheng-mu| Wang, Yong-wei| Wang, Min| Cheng, Wei-wei

Reproductive Medical Center, International Peace Maternity and Child Health Hospital Affiliated, Shanghai Jiao Tong University, School of Medicine, Shanghai, China.| Reproductive Medical Center, International Peace Maternity and Child Health Hospital

AIM: The expression of aromatase (via CYP19 and the CYP19 PII promoter) and the orphan nuclear receptor family members, liver receptor homologue-1 (LRH-1) and steroidogenic factor-1 (SF-1) in cultured luteinized granulosa cells from women with endometriosis were investigated. METHODS: Luteinized granulosa cells from patients undergoing in vitro fertilization (16 patients with endometriosis and 28 controls) were examined for messenger ribonucleic acid (mRNA) expression of CYP19, CYP19 PII, LRH-1 and SF-1, determined by quantitative reverse transcription-polymerase chain reaction. Student's t-test, the Mann-Whitney U test and Spearman's rank correlation were used for statistical analysis. RESULTS: The number of high quality embryos in the endometriosis group was significantly lower than in the control group. The mRNA expression levels of CYP19, CYP19 PII, LRH-1 and SF-1 in granulosa-lutein cells were decreased in women with endometriosis compared to the control group. The simultaneous down-regulation expression of LRH-1, SF-1 and CYP19 PII in endometriotic granulosa cells indicated their positive correlation. CONCLUSION: Our results demonstrate aberrant expressions of SF-1 and LRH-1 in endometriotic granulosa-lutein cells. This finding may be helpful in understanding infertility associated with endometriosis and reduced P450 aromatase activity in endometriotic granulosa cells.

Mesh Terms: Adult| Aromatase/genetics| Cells, Cultured| Endometriosis/*metabolism| Female| Granulosa Cells/*metabolism| Humans| RNA, Messenger/analysis| Receptors, Cytoplasmic and Nuclear/*genetics| Steroidogenic Factor 1/*genetics|DA 2017/01/12 06:00