Results
| PMID | 28030938 |
| Gene Name | TIMP1 |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 42 |
| Population details | 42 (18 ((n=14; primary – 11, secondary – 3), suspicion of endometriosis (n=7), recurrent miscarriages (n=4) or bilateral occlusion of the fallopian tubes (n=2)), 22 in thecontrol group( infertility (n=16; primary – 13, secondary – 3; among them, male factor – 3), occlusion of the fallopian tubes (n=11; bilateral – 5, unilateral – 6), uterine fibroids (n=5), recurrent miscarriages (n=3) or suspicion of endometriosis (n=1))) |
| Age | Endometriosis: Mean age-29.2 yrs; Controls: Mean age- 29.6 years |
| Sex | Female |
| Infertility type | Female infertility |
| Associated genes | MMP2, MMP9, TIMP1, TGFB2 |
| Other associated phenotypes |
Peritoneal endometriosis |
|
Ann Agric Environ Med. 2016 Dec 23;23(4):649-653. doi: 10.5604/12321966.1226861. Szymanowski, Krzysztof| Mikolajczyk, Mateusz| Wirstlein, Przemyslaw| Dera-Szymanowska, Anna Department of Mother's and Child's Health, Poznan University of Medical Sciences, Poland.| Department of Obstetrics and Gynecology, Division of Reproduction, Poznan University of Medical Sciences, Poland.| Department of Obstetrics and Gynecology, Divi INTRODUCTION: The prevalence of endometriosis among reproductive age women is 7-17%; however, these figures reach 20-50% in patients suffering from infertility. Matrix metalloproteinases (MMPs) activity is thought to be particularly essential in the early phases of endometriosis development. Any changes in the equilibrium between MMPs activity and their tissue inhibitors (TIMPs) could be potentially harmful, promoting endometriosis development. The aim of this study was to investigate whether the MMP-2, MMP-9, TIMP-1 or TGF-B2 expression in eutopic endometrium from women with early endometriosis differ when compared with healthy subjects. The results were referred to the serum progesterone levels. MATERIALS AND METHOD: Endometrial biopsy was taken from 42 patients (18 in the study group, 22 in thecontrol group) at the time of hysteroscopy for routine histology and for RT-PCR procedures. Comparison of the quantity of gene products was performed with a programme for densitometry and compared to GADPH product, which was a reference value. RESULTS: The obtained results did not reveal any statistical difference in endometrial expression of MMP-2, MMp-9, TIMP-1, and TGF-beta2 or serum progesterone level between women with endometriosis and without visible signs of this illness. CONCLUSION: Despite the lack of statistical differences, it was observed that both examined metalloproteinases expressed a tendency to higher gene expression in the eutopic endometrium of women with endometriosis. However, both TIMP-1 and TGF-beta2 expressions had the same tendency - higher values in endometriosis patients. Mesh Terms: Adult| Collagenases/*genetics/metabolism| Endometriosis/enzymology/genetics/*physiopathology| Endometrium/*metabolism| Female| *Gene Expression Regulation| Humans| Tissue Inhibitor of Metalloproteinase-1/*genetics/metabolism| Transforming Growth F |
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