Results
| PMID | 28075439 |
| Gene Name | S100A6 |
| Condition | Endometriosis |
| Association |
Associated |
| Sex | Female |
| Other associated phenotypes |
Endometriosis |
|
Mol Med Rep. 2017 Mar;15(3):1279-1285. doi: 10.3892/mmr.2017.6105. Epub 2017 Jan Zhang, Xiaoling| Liu, Zequn| Chen, Meihong| Cao, Qing| Huang, Donghua Department of Gynecology, Jiangxi Maternal and Child Health Hospital, Nanchang University, Nanchang, Jiangxi 330006, P.R. China.| Department of Medicine, Nanchang University, Nanchang, Jiangxi 330006, P.R. China.| Department of Gynecology, Jiangxi Mat Protein expression levels of S100 calcium binding protein A6 (S100A6) are increased in various malignancies and are associated with tumor behavior; however, the association between S100A6 and endometriosis remains to be elucidated. In order to investigate the influence of S100A6 protein, recombinant lentivirus siS100A6 was used to transfect the eutopic endometrial stromal cells. CCK8 assay was performed to identify the proliferation ability of cell and the cell migration was detected by Transwell assay. Flow cytometry was performed to detect cell apoptosis, and western blotting and reverse transcriptionquantitative polymerase chain reaction were performed to identify the expression of betacatenin. The present study investigated the role of S100A6 in endometriosis and its interaction with betacatenin by transfecting eutopic endometrial stromal cells with a recombinant lentivirus containing S100A6specific small interfering RNA. Inhibition of S100A6 expression had a significant antiproliferative effect and reduced the migratory ability of eutopic endometrial stromal cells, and induced their apoptosis. In addition, inhibition of S100A6 expression suppressed betacatenin expression. These results suggested that inhibition of S100A6 may represent a promising novel approach for the targeted therapy of endometriosis. Mesh Terms: Adult| Apoptosis| Cell Cycle Proteins/*genetics/metabolism| Cell Movement| Cell Proliferation| Endometriosis/genetics/metabolism/pathology| Endometrium/*metabolism| Female| Gene Expression| *Gene Expression Regulation| *Gene Silencing| Genes, R |
|