Results
| PMID | 29202955 |
| Gene Name | LGALS9 |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 135 |
| Population details | 135 (77 endometriosis patients, 28 gynecologic controls, 30 healthy women) |
| Sex | Female |
| Infertility type | Female infertility |
| Other associated phenotypes |
Endometriosis, infertility, pelvic pain |
|
Fertil Steril. 2017 Dec;108(6):1016-1025.e2. doi: Brubel, Reka| Bokor, Attila| Pohl, Akos| Schilli, Gabriella Krisztina| Szereday, Laszlo| Bacher-Szamuel, Reka| Rigo, Janos Jr| Polgar, Beata First Department of Obstetrics and Gynaecology, Semmelweis University, Budapest, Hungary.| First Department of Obstetrics and Gynaecology, Semmelweis University, Budapest, Hungary.| First Department of Obstetrics and Gynaecology, Semmelweis Universi OBJECTIVE: To investigate the usefulness of soluble galectin-9 (Gal-9) in the noninvasive laboratory diagnosis of endometriosis and various gynecologic disorders. DESIGN: Prospective case-control study. SETTING: University medical centers. PATIENT(S): A total of 135 women of reproductive age were involved in the study, 77 endometriosis patients, 28 gynecologic controls, and 30 healthy women. INTERVENTION(S): Diagnostic laparoscopy and collection of tissue biopsies, peritoneal cells, and native peripheral blood from different case groups of gynecology patients and healthy women. MAIN OUTCOME MEASURE(S): The expression of mRNA and serum concentration of Gal-9. RESULT(S): Semiquantitative reverse transcription-polymerase chain reaction analysis and serum soluble Gal-9 ELISA were performed on three different cohorts of patients: those with endometriosis, those with benign gynecologic disorders, and healthy controls. Differences in the Gal-9 concentrations between the investigated groups and the stability of Gal-9 in the serum and diagnostic characteristics of Gal-9 ELISA were determined by statistical evaluation and receiver operating characteristic (ROC) curve analysis. Significantly elevated Gal-9 levels were found in both minimal-mild (I-II) and moderate-severe (III-IV) stages of endometriosis in comparison with healthy controls. At a cutoff of 132 pg/mL, ROC analysis revealed an excellent diagnostic value of Gal-9 ELISA in endometriosis (area under the curve = 0.973) with a sensitivity of 94% and specificity of 93.75%, indicating better diagnostic potential than that of other endometriosis biomarkers. Furthermore, various pelvic pain or infertility-associated benign gynecologic conditions were also associated with increased serum Gal-9 levels. CONCLUSION(S): Our results suggest that Gal-9 could be a promising noninvasive biomarker of endometriosis and a predictor of various infertility or pelvic pain-related gynecologic disorders. Mesh Terms: Adult| Area Under Curve| Biomarkers/blood| Case-Control Studies| Endometriosis/*blood/complications/diagnosis/genetics| Enzyme-Linked Immunosorbent Assay| Female| Galectins/*blood/genetics| Humans| Infertility, Female/*blood/diagnosis/etiology/ge |
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