Results
| PMID | 29304094 |
| Gene Name | MMP9 |
| Condition | Endometriosis |
| Association |
Associated |
| Sex | Female |
| Associated genes | STIP1, MMP9 |
| Other associated phenotypes |
Endometriosis |
|
PLoS One. 2018 Jan 5;13(1):e0190573. doi: 10.1371/journal.pone.0190573. Wang, Hsin-Shih| Tsai, Chia-Lung| Chang, Pi-Yueh| Chao, Angel| Wu, Ren-Chin| Chen, Shun-Hua| Wang, Chin-Jung| Yen, Chih-Feng| Lee, Yun-Shien| Wang, Tzu-Hao Department of Obstetrics and Gynecology, LinKou Medical Center, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan.| Genomic Medicine Research Core Laboratory, Chang Gung Memorial Hospital, Taoyuan, Taiwan.| Department of Laborato Stress-induced phosphoprotein-1 (STIP1), an adaptor protein that coordinates the functions of HSP70 and HSP90 in protein folding, has been implicated in the development of human gynecologic malignancies. This case-control study investigates STIP1 serum levels and tissue expression in relation to endometriosis/adenomyosis in Taiwanese population. Female patients with surgically confirmed endometriosis/adenomyosis were compared with women free of endometriosis/adenomyosis. Serum STIP1 levels were measured using an enzyme-linked immunosorbent assay and surgical tissues were analyzed by immunohistochemistry. Both epithelial and stromal cells in surgical tissues of endometriosis and adenomyosis expressed STIP1 and MMP-9. Notably, MMP-9 expression was significantly decreased when STIP1 expression was knocked-down. In vitro experiments revealed that STIP1 was capable of binding to the MMP-9 promoter and enhanced its transcriptional expression. The preoperative serum STIP1 levels of patients with endometriosis/adenomyosis were significantly higher than those of the controls. In brief, our data suggest an association between STIP1 levels and endometriosis/adenomyosis. Mesh Terms: Adult| Case-Control Studies| Cell Line, Tumor| Endometriosis/*enzymology| Enzyme-Linked Immunosorbent Assay| Female| Heat-Shock Proteins/blood/genetics/*metabolism| Humans| Immunohistochemistry| Matrix Metalloproteinase 9/genetics/*metabolism| P |
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