Results
| PMID | 29630856 |
| Gene Name | CSE1L |
| Condition | Endometriosis |
| Association |
Associated |
| Sex | Female |
| Associated genes | CAS, CD147, nuclearB-cat |
| Other associated phenotypes |
Endometriosis |
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Am J Pathol. 2018 Apr 6. pii: S0002-9440(17)30969-0. doi: Wang, Chaoqun| Zhang, Jieting| Fok, Kin Lam| Tsang, Lai Ling| Ye, Mei| Liu, Jianni| Li, Fanghong| Zhao, Allan Zijian| Chan, Hsiao Chang| Chen, Hao Epithelial Cell Biology Research Center, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong.| Epithelial Cell Biology Research Center, School of Biomedical Sciences, Faculty of Medicine, The Chine Epithelial-to-mesenchymal transition (EMT) is postulated to be a prerequisite for the establishment of endometriosis (EMS), a common reproductive disorder in women. Our previous studies have demonstrated the elevated expression of transmembrane glycoprotein CD147 and its prosurvival effect on abnormal cells in endometriosis. Intriguingly, CD147 is known to promote EMT in cancers. However, the involvement of CD147 in EMT during the establishment of endometriosis remains incompletely understood. We found that CD147 promotes EMT in human endometrial adenocarcinoma cell line Ishikawa. We identified a novel CD147-interacting partner, cellular apoptosis susceptibility protein (CAS), which stabilized the interaction between E-cadherin (E-cad) and beta-catenin (beta-cat) by forming the CAS/E-cad/beta-cat complex. Down-regulation of CAS led to the release and nuclear translocation of beta-cat from E-cad, resulting in the overexpression of the EMT-promoting gene SNAIL. Interestingly, overexpression of CD147 impaired the interaction between CAS and E-cad and triggered the release of beta-cat from the CAS/E-cad/beta-cat complex, which in turn led to EMT. Furthermore, CAS was down-regulated in EMS, with elevated levels of CD147 and nuclear beta-cat. These findings suggest a previously undefined role of CAS in regulating EMT and reveal the involvement of a CD147-induced EMT signaling pathway in pathogenic progression of EMS. Mesh Terms: DA2018/04/10 06:00 |
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