Results
| PMID | 6208058 |
| Gene Name | C4A |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 102 |
| Population details | 102 infertile patients with and without endometriosis |
| Sex | Female |
| Associated genes | C3c and C4 |
| Other associated phenotypes |
Endometriosis |
|
Fertil Steril. 1984 Nov;42(5):704-8. Badawy, S Z| Cuenca, V| Marshall, L| Munchback, R| Rinas, A C| Coble, D A Cellular components in peritoneal fluid of infertile patients with and without endometriosis were evaluated in 102 patients with Wright's-Giemsa and Papanicolaou stains. The secretory activity of these cells was studied indirectly by assaying acid phosphatase, prostaglandin (PG) F2 alpha and PGE2 and complement components C3c and C4. The results showed that macrophages and lymphocytes were the dominant cells in peritoneal fluid of these patients. These cells were significantly increased in endometriosis patients, as compared with control subjects. In addition, peritoneal fluid acid phosphatase, PGF2 alpha and PGE2, and complement components C3c and C4 were significantly increased in patients with endometriosis. These cellular changes and their activation in peritoneal fluid may explain infertility associated with endometriosis. Mesh Terms: Acid Phosphatase/analysis| Adolescent| Adult| Ascitic Fluid/metabolism/*pathology| Complement C3/analysis| Complement C3c| Complement C4/analysis| Dinoprost| Dinoprostone| Endometriosis/complications/*pathology| Fallopian Tube Patency Tests| Fe |
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