Results
| PMID | 7904954 |
| Gene Name | IL5 |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 55 |
| Population details | 55 (32 patients had pelvic endometriosis, 8 post-pelvic inflammatory disease, 4 advanced cancer, 3 adenomyosis, 3 benign ovarian tumor, and other diseases) |
| Sex | Female |
| Associated genes | IL-5, IL-6, IL-1 |
| Other associated phenotypes |
Endometriosis |
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Int J Gynaecol Obstet. 1993 Oct;43(1):45-50. Koyama, N| Matsuura, K| Okamura, H Department of Obstetrics and Gynecology, Kumamoto University School of Medicine, Japan. OBJECTIVE: To determine which of the various cytokines interleukin-5 (IL-5), interleukin-6 (IL-6) and interleukin-1 (IL-1) are important in endometriosis. METHODS: Peritoneal fluid (PF) samples were taken from 55 women at the time of either laparotomy or laparoscopy, and were examined for the levels of IL-5, IL-6 and IL-1 using each cytokine specific sandwich enzyme-linked immunosorbent assay. Thirty-two patients had pelvic endometriosis, eight post-pelvic inflammatory disease, four advanced cancer, three adenomyosis, three benign ovarian tumor, and other diseases. Statistical analysis was performed with the Mann Whitney test, chi-square test or Fisher's test. RESULTS: Both IL-5 and IL-6 levels in PF specimens with endometriosis tended to be higher than normal, while the same specimens were mostly interleukin-1 beta (IL-1 beta) negative. Of great interest was the negative correlation between log (IL-5) and IL-6 (Fisher's test, P < 0.04). CONCLUSION: These findings support the concept that IL-5 and IL-6 but not IL-1 are associated with endometriosis. Mesh Terms: Adult| Ascitic Fluid/etiology/*metabolism| Cytokines/*analysis/physiology| Endometriosis/*complications| Enzyme-Linked Immunosorbent Assay| Female| Humans| Infertility, Female/etiology| Interleukin-5/analysis| Interleukin-6/analysis| Middle Aged |
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