Results
| PMID | 8194621 |
| Gene Name | EDN1 |
| Condition | Endometriosis |
| Association |
Associated |
| Sex | Female |
| Infertility type | Female infertility |
| Associated genes | Endothelin-1 |
| Other associated phenotypes |
Endometriosis-associated infertility |
|
Fertil Steril. 1994 Jun;61(6):1083-7. Abae, M| Glassberg, M| Majercik, M H| Yoshida, H| Vestal, R| Puett, D Department of Obstetrics and Gynecology, University of Miami School of Medicine, Florida. OBJECTIVE: To determine the concentrations of immunoreactive (IR) endothelin-1 in human follicular fluid (FF) and whether IR-endothelin-1 levels are different in women with endometriosis-associated infertility. DESIGN: Follicular fluid and plasma samples, obtained from women with and without endometriosis undergoing IVF-ET, were collected at the time of oocyte aspiration and analyzed for IR-endothelin-1 levels. SETTING: Infertility clinic in an academic research environment. RESULTS: Overall, 90% of FF samples and 60% of plasma samples contained IR-endothelin-1 detectable above the threshold of assay sensitivity. Immunoreactive endothelin-1 levels (mean +/- SEM) in FF samples from women with and without endometriosis-associated infertility were 74 +/- 12 and 37 +/- 6 pg/mL, respectively. There was no difference in IR-endothelin-1 levels in FF samples between controlled ovarian hyperstimulation cycles with or without leuprolide acetate. No significant differences were detected in plasma IR-endothelin-1 levels in women with endometriosis-associated infertility when compared with those without. CONCLUSIONS: These results demonstrate the presence of IR-endothelin-1 in human FF obtained at the time of oocyte aspiration for IVF-ET and higher levels of IR-endothelin-1 in FF of women with endometriosis-associated infertility. Mesh Terms: Adult| Chromatography, High Pressure Liquid| *Embryo Transfer| Endometriosis/complications/*metabolism| Endothelins/*analysis/*immunology/metabolism| Female| *Fertilization in Vitro| Follicular Fluid/*chemistry| Humans| Infertility, Female/etiolo |
|