Results
| PMID | 9065123 |
| Gene Name | IL6 |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 27 |
| Population details | 27 (15 patients, 12 controls) |
| Sex | Female |
| Associated genes | IL-6, IL-10, IL-2, IL-4, IL-5, GM-CSF |
| Other associated phenotypes |
Endometriosis |
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Am J Obstet Gynecol. 1996 May;174(5):1522-6. Punnonen, J| Teisala, K| Ranta, H| Bennett, B| Punnonen, R Department of Medical Microbiology, University of Turku, Finland. OBJECTIVE: The levels of interleukin-2, interleukin-4, interleukin-5, interleukin-6, interleukin-10, and granulocyte-macrophage colony-stimulating factor were measured in the peritoneal fluid of 15 patients with endometriosis to characterize the type of immune response that occurs at the site of endometriosis. STUDY DESIGN: Cytokine levels in peritoneal fluid obtained during laparoscopy from 15 patients and 12 controls undergoing tubal ligation were determined by enzyme-linked immunosorbent assay. RESULTS: The mean levels of interleukin-6 in patients with endometriosis and controls were 797 +/- 407 pg/ml and 133 +/- 38 pg/ml, respectively (p < 0.02). Similarly, the mean concentration of interleukin-10 in peritoneal fluids of patients with endometriosis was significantly higher than that of controls (241 +/- 38 vs 128 +/- 21, p < 0.05). The levels of interleukin-2, interleukin-4, interleukin-5, and granulocyte-macrophage colony-stimulating factor were not significantly different between the two study groups. CONCLUSIONS: The levels of interleukin-6 and interleukin-10 are increased in the peritoneal fluids of patients with endometriosis, suggesting enhanced macrophage activity in these patients. Increased interleukin-6 and interleukin-10 production may partially contribute to the disturbed immune regulation observed in patients with endometriosis. Mesh Terms: Adult| Ascitic Fluid/*metabolism| Endometriosis/*metabolism| Enzyme-Linked Immunosorbent Assay| Female| Granulocyte-Macrophage Colony-Stimulating Factor/metabolism| Humans| Interleukin-10/*metabolism| Interleukin-6/*metabolism|DA 1996/05/01 00:01 |
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