Results
| PMID | 9458291 |
| Gene Name | NME1 |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 16 |
| Population details | 16 patients with histologically verified pelvic endometriosis |
| Sex | Female |
| Associated genes | c-myc, c-erb-B2, nm23 and p53 |
| Other associated phenotypes |
Endometriosis |
|
Oncol Rep. 1998 Jan-Feb;5(1):49-52. Schneider, J| Jimenez, E| Rodriguez, F| del Tanago, J G Hospital de Cruces, Departamento de Ginecologia, Baracaldo, Spain. We studied the expression of oncogenes and tumor-suppressor genes in human endometriosis in a retrospective pilot study. Sixteen patients with histologically verified pelvic endometriosis at the university-based tertiary care referral center were studied. Immunohistochemical determination of c-myc, c-erb-B2, nm23 and p53 expression in archival, paraffin-embedded pathological samples were used from patients operated upon for pelvic endometriosis. c-myc was expressed in 8/15 cases (53.3%). nm23 was expressed in 7/16 cases (43.7%). c-erb-B2 and p53 reactivity was undetectable in the samples studied. The c-myc oncogene and nm23 are overexpressed in many cases of endometriosis, and may play a still undefined role in its pathogenesis. Immuno-histochemistry is a useful tool for the study of oncogenic activation in this disease. Mesh Terms: Biopsy| Endometriosis/genetics/metabolism/*pathology| Female| *Genes, Tumor Suppressor| *Genes, erbB-2| *Genes, myc| Genes, p53| Humans| *Monomeric GTP-Binding Proteins| NM23 Nucleoside Diphosphate Kinases| *Nucleoside-Diphosphate Kinase| Proto |
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