Results
| PMID | 9764347 |
| Gene Name | TF |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 228 |
| Population details | 228 (105 normal women, 123 patients with active endometriosis) |
| Sex | Female |
| Associated genes | Transferrin, alpha 2-HS glycoprotein |
| Other associated phenotypes |
Endometriosis |
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Am J Reprod Immunol. 1998 Aug;40(2):69-73. Mathur, S P| Holt, V L| Lee, J H| Jiang, H| Rust, P F Department of Obstetrics and Gynecology and Biometry, Medical University of South Carolina, Charleston 29425, USA. PROBLEM: To establish an enzyme-linked immunosorbent assay (ELISA) for determining the levels of antibodies to transferrin and alpha 2-HS glycoprotein in the serum of women with and without endometriosis. METHOD OF STUDY: Serum samples were obtained from 105 normal women, who were randomly selected for a population-based epidemiologic study, and 123 patients with active endometriosis. An ELISA using transferrin and alpha 2-HS glycoprotein as antigens was established. RESULTS: The levels of antibodies to transferrin and alpha 2-HS glycoprotein in the serum of patients with endometriosis were approximately 21 times higher than those in the serum of control subjects without endometriosis. Only 2% of control subjects had false positive levels of these antibodies, and 5% of patients with endometriosis had false negative levels of these antibodies (specificity, 98.1 and 98.1, respectively, for anti-transferrin and anti-alpha 2-HS glycoprotein; sensitivity, 95 and 96.7, respectively, for anti-transferrin and anti-alpha 2-HS glycoprotein). CONCLUSIONS: Patients with endometriosis have significantly higher levels of antibodies to transferrin and alpha 2-HS glycoprotein than control subjects. Testing women for antibodies to transferrin and alpha 2-HS glycoprotein will provide a specific noninvasive diagnosis of endometriosis. Mesh Terms: Adolescent| Adult| Antibodies/*blood| Blood Proteins/*immunology| Endometriosis/*diagnosis/immunology| Enzyme-Linked Immunosorbent Assay/*methods| Female| Humans| Middle Aged| Transferrin/*immunology| alpha-2-HS-Glycoprotein|DA 1998/10/09 00:01 |
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