Endometriosis Knowledgebase


A repository for genes associated with endometriosis

Results


PMID 9920107
Gene Name TYMP
Condition Endometriosis (Ovarian)
Association Associated
Sex Female
Associated genes PD-ECGF
Other associated phenotypes Ovarian endometriosis
Expression of platelet-derived endothelial cell growth factor (PD-ECGF) related to angiogenesis in ovarian endometriosis.

J Clin Endocrinol Metab. 1999 Jan;84(1):359-62.

Fujimoto, J| Sakaguchi, H| Hirose, R| Tamaya, T

Department of Obstetrics and Gynecology, Gifu University School of Medicine, Gifu City, Japan.

Platelet-derived endothelial cell growth factor (PD-ECGF) is expressed in the lining epithelial cells of ovarian endometriomas, and in interstitial cells of the subepithelial area with angiogenesis. The expression of PD-ECGF persists in endometriotic endometrium during the menstrual cycle. This might suggest that PD-ECGF contributes to the growth of ovarian endometriomas via subepithelial angiogenesis independently of the sex steroidal milieu.

Mesh Terms: Adult| Endometriosis/*etiology/metabolism| Female| Humans| Immunohistochemistry| Neovascularization, Pathologic/*complications| Ovarian Diseases/*etiology| RNA, Messenger/analysis| Thymidine Phosphorylase/*analysis/genetics|DA 1999/01/27 00:01